Numbers by MacKenzie Mauger
When you hear the word shrooms online Canada, you will think of hallucinations and mystical experiences. Popular psychedelics include LSD (lysergic acid diethylamide), psilocybin mushrooms (including psychedelic thyrosibin), and DMT (N, N-dimethyltryptamine, part of psychiatric ayahuasca), all of which are commonly found. "trip". However, there is increasing pressure in the scientific community to study these well-known recreational drugs as treatments for mental states that have fewer side effects and may be more effective than traditional psychiatric drugs. ..
This psychedelic interest in psychedelics is nothing new. In the 1950s and 1960s, thousands of patients were experimentally given a variety of psychedelic drugs to treat alcoholism and other psychiatric disorders. Much of this research did not stop until the US Controlled Substances Act of 1971 was passed. After nearly 40 years of rest in the study, scientists have begun to resume the study. Historical studies in 2014 and 2016 have already shown that LSD and psilocybin improve mood and anxiety in patients with a variety of life-threatening illnesses for up to a year after treatment, respectively, and more studies are underway. is.
In addition to this new interest in psychedelics, there is an increasingly popular approach known as microdosing. Microdosing is when a patient has too low a dose of psychedelic to get a noticeable effect, usually 5-10% of the standard dose. Despite taking small doses of the drug, microdosing may offer some of the benefits seen with full-dose treatment without causing intense and sometimes negative hallucinatory experiences. There is evidence of. Nonetheless, some scientists are skeptical that these results are false or, worse, microdosing can even be harmful.
Psychedelic drugs are primarily known to affect serotonin, a chemical messenger that helps nerve cells communicate with other cells in the body. Serotonin is commonly described in the media as a cause of well-being, but in reality its function is much more complex and widespread. In fact, serotonin is associated not only with mood, but also with physiological processes such as cognition, sleep, diet, thermoregulation, memory, and even vomiting.
Because serotonin is so important in the body, it has a molecular region called the serotonin 2A receptor located in the central nervous system. Chemicals can bind to these receptors and stimulate or block the serotonin system. Although this mechanism is not fully understood, these receptors are thought to be targets of psychedelic drugs. One hypothesis is that when these drugs bind to serotonin 2A receptors, the cerebral cortex, which is involved in cognitive, sensory, and motor function, is excited, ultimately leading to hallucinations and other effects. Some studies have shown that psychedelics increase neuroplasticity, lead to the creation of more connections between neurons, and perhaps explain the novelty of these intense psychological experiences. Therefore, microdosing works the same, albeit mildly.
Some studies also suggest that microdosing may work by fighting inflammation in the body. Inflammation is the result of the body's immune system protecting you from infection, but it can cause damage if the immune system is activated without real risk. Long-term or chronic inflammation is associated with many conditions, including psychiatric disorders such as autoimmune disorders and depression. Animal studies have shown the anti-inflammatory effect of microdosing, and some scientists speculate that it may indicate another possible mechanism of action.